Selected article for: "cell target and immune response"
Author: Ding, Peiyang; Zhang, Teng; Li, Yafei; Teng, Man; Sun, Yaning; Liu, Xiao; Chai, Shujun; Zhou, Enmin; Jin, Qianyue; Zhang, Gaiping
Title: Nanoparticle orientationally displayed antigen epitopes improve neutralizing antibody level in a model of porcine circovirus type 2
  • Document date: 2017_7_24
    • ID: upb97on4_62
    Snippet: The mechanism that AuNPs improved the NA level of Cap-based PCV2 subunit vaccine can be attributed to two aspects: first, although Cap protein bound to AuNPs at a very low percentage (0.6%) of total immunized protein, this part of binding protein was efficiently taken up by APCs and played a key role in activating the immune response. Each AuNP was capable of displaying 6-fold the amount of Cap protein than PCV2, resulting in a higher degree of B.....
    Document: The mechanism that AuNPs improved the NA level of Cap-based PCV2 subunit vaccine can be attributed to two aspects: first, although Cap protein bound to AuNPs at a very low percentage (0.6%) of total immunized protein, this part of binding protein was efficiently taken up by APCs and played a key role in activating the immune response. Each AuNP was capable of displaying 6-fold the amount of Cap protein than PCV2, resulting in a higher degree of BCR cross-linking. The second and more important point, AuNPs directionally presented multiple neutralizing epitopes; thus, B cells simultaneously recognized more neutralizing epitopes, resulting in rapid proliferation of B-cell clones, which specifically target the neutralizing epitopes. Meanwhile AuNPs shielded the immunodominant epitope Cap (169-180), effectively reducing the antibody against this epitope, which plays a negative role in the production of NA.

    Search related documents:
    Co phrase search for related documents
    • bind protein and Cap protein: 1, 2
    • bind protein and high degree: 1
    • bind protein and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
    • Cap protein and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • cross link and immune response: 1, 2