Author: Jordan, Paul C; Stevens, Sarah K; Deval, Jerome
Title: Nucleosides for the treatment of respiratory RNA virus infections Document date: 2018_3_21
ID: txaoz7oh_9
Snippet: The recognized advantages of direct-acting agent nucleosides over other classes of antiviral agents are (1) their propensity to cover a broad-spectrum of virus strains and sometimes species and (2) their high barrier to antiviral resistance. Both properties are best explained by the mechanism of action common to most antiviral nucleosides: targeting viral polymerases. 43 After being metabolized by host kinases to their triphosphate form, antivira.....
Document: The recognized advantages of direct-acting agent nucleosides over other classes of antiviral agents are (1) their propensity to cover a broad-spectrum of virus strains and sometimes species and (2) their high barrier to antiviral resistance. Both properties are best explained by the mechanism of action common to most antiviral nucleosides: targeting viral polymerases. 43 After being metabolized by host kinases to their triphosphate form, antiviral nucleotides compete with natural nucleoside triphosphates (NTPs) to bind to the active site of viral polymerases and alter DNA or RNA synthesis. The nucleotide binding site of these proteins is usually well conserved among virus families and any changes in neighboring amino acids often comes at a cost for the enzyme and the virus. The functional and structural features of RNA polymerases of respiratory viruses targeted by antiviral nucleosides are described in the following paragraphs.
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