Author: Willemsen, Anouk; Zwart, Mark P
Title: On the stability of sequences inserted into viral genomes Document date: 2019_11_14
ID: vv5gpldi_42
Snippet: Sequence redundancy due to a promoter duplication can also lead to genomic instability and thus the subsequent deletion of the inserted sequence (Dawson et al. 1989; Chapman, Kavanagh, and Baulcombe 1992) . Indeed, for TMV and PVX it has been shown that replacing one of the promoter sequences with that from related viruses (Donson et al. 1991) together with further removal of additional sequence duplications (Dickmeis, Fischer, and Commandeur 201.....
Document: Sequence redundancy due to a promoter duplication can also lead to genomic instability and thus the subsequent deletion of the inserted sequence (Dawson et al. 1989; Chapman, Kavanagh, and Baulcombe 1992) . Indeed, for TMV and PVX it has been shown that replacing one of the promoter sequences with that from related viruses (Donson et al. 1991) together with further removal of additional sequence duplications (Dickmeis, Fischer, and Commandeur 2014) , leads to increased stability of the insert.
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