Author: Willemsen, Anouk; Zwart, Mark P
Title: On the stability of sequences inserted into viral genomes Document date: 2019_11_14
ID: vv5gpldi_56
Snippet: Canine distemper virus (CDV), a species in the Morbillivirus genus, is an important pathogen of a variety of animals, including the dog. This virus, however, has shown to be a promising expression vector for the development of vaccines. Although the replicative fitness of a recombinant CDV carrying the rabies virus glycoprotein was slightly lower than the wild-type CDV, the insert was stably expressed during serial passaging in vitro and inoculat.....
Document: Canine distemper virus (CDV), a species in the Morbillivirus genus, is an important pathogen of a variety of animals, including the dog. This virus, however, has shown to be a promising expression vector for the development of vaccines. Although the replicative fitness of a recombinant CDV carrying the rabies virus glycoprotein was slightly lower than the wild-type CDV, the insert was stably expressed during serial passaging in vitro and inoculation in vivo induced specific neutralizing antibodies against both rabies and CDV .
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