Author: Willemsen, Anouk; Zwart, Mark P
Title: On the stability of sequences inserted into viral genomes Document date: 2019_11_14
ID: vv5gpldi_80
Snippet: Sequence loss is inherently an evolutionary process, at a minimum involving mutation and selection, and therefore needs to be framed in an evolutionary context. Here, we consider how theory might help to better understand and ultimately predict this process. First, inspired by empirical results we consider the effects of virus population and bottleneck sizes on sequence loss. Second, we consider whether there are different evolutionary trajectori.....
Document: Sequence loss is inherently an evolutionary process, at a minimum involving mutation and selection, and therefore needs to be framed in an evolutionary context. Here, we consider how theory might help to better understand and ultimately predict this process. First, inspired by empirical results we consider the effects of virus population and bottleneck sizes on sequence loss. Second, we consider whether there are different evolutionary trajectories that lead to a restoration of fitness following insertion of a sequence, and their implications for sequence stability.
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