Author: Willemsen, Anouk; Zwart, Mark P
Title: On the stability of sequences inserted into viral genomes Document date: 2019_11_14
ID: vv5gpldi_85
Snippet: Demography can also modulate the strength of selection itself. The MOI (cellular multiplicity of infection) is a key demographic parameter at the cellular level, as it describes the number of virus particles infecting a cell. If an inserted sequence affects viral fitness in trans at the within cell level-for example by being toxic-then the MOI will determine whether there can be selection (Miyashita and Kishino 2010) . At high MOIs there will be .....
Document: Demography can also modulate the strength of selection itself. The MOI (cellular multiplicity of infection) is a key demographic parameter at the cellular level, as it describes the number of virus particles infecting a cell. If an inserted sequence affects viral fitness in trans at the within cell level-for example by being toxic-then the MOI will determine whether there can be selection (Miyashita and Kishino 2010) . At high MOIs there will be no selection, because the toxin is produced in all cells and affects the replication of both producers and nonproducers of the toxin (Fig. 3 ). An interesting conundrum is that high MOIs also tend to promote the evolution of DI viruses (Huang 1973) due to within-cell selection, and hence these two effects must be weighed accordingly.
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