Author: Huo, Caiyun; Xiao, Jin; Xiao, Kai; Zou, Shumei; Wang, Ming; Qi, Peng; Liu, Tianlong; Hu, Yanxin
Title: Pre-Treatment with Zirconia Nanoparticles Reduces Inflammation Induced by the Pathogenic H5N1 Influenza Virus Document date: 2020_1_30
ID: wqzve7i5_36_1
Snippet: thus preventing lung injury and improving the survival rate of the infected mice. a mouse model and the mechanism of action of these NPs. Several studies have shown that positive charges can facilitate retention of NPs in cells for a relatively long time, which is likely related to intracellular agglomeration. The native surface chemistries of NPs also play crucial roles in their exocytosis patterns from cells. Here, we provide the first data tha.....
Document: thus preventing lung injury and improving the survival rate of the infected mice. a mouse model and the mechanism of action of these NPs. Several studies have shown that positive charges can facilitate retention of NPs in cells for a relatively long time, which is likely related to intracellular agglomeration. The native surface chemistries of NPs also play crucial roles in their exocytosis patterns from cells. Here, we provide the first data that positively-charged ZrO 2 NPs can downregulate the levels of pro-inflammatory cytokines and thereby alleviate the inflammatory response, making them effective anti-inflammatory agents against highly pathogenic H5N1 influenza virus.
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