Author: Choi, Kang-Seuk
Title: Newcastle disease virus vectored vaccines as bivalent or antigen delivery vaccines Document date: 2017_7_26
ID: vk59ghjm_10
Snippet: NDV vaccine strains infect many mammals but are very safe due to restricted host tropism. Nevertheless, NDV is a strong stimulator of humoral and cellular immune responses at both the local and systemic levels; it also has an adjuvant effect [8] . Importantly, NDV is antigenically distinct from known paramyxoviruses that infect mammals; thus it is unlikely to be affected by pre-existing immunity in mammals [8] . NDV does not establish persistent .....
Document: NDV vaccine strains infect many mammals but are very safe due to restricted host tropism. Nevertheless, NDV is a strong stimulator of humoral and cellular immune responses at both the local and systemic levels; it also has an adjuvant effect [8] . Importantly, NDV is antigenically distinct from known paramyxoviruses that infect mammals; thus it is unlikely to be affected by pre-existing immunity in mammals [8] . NDV does not establish persistent infection in animals and humans because it replicates only in the cytoplasm [8] . In addition, the rule of six means that genetic changes (e.g., insertions, deletions, and recombinations) affecting the integrity of the genome are rare [8] . Therefore, NDV vaccine strains are potential virus vectors that can be used to develop antigen delivery vaccines for use in animals and/or humans.
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