Author: Chang, Stewart T.; Thomas, Matthew J.; Sova, Pavel; Green, Richard R.; Palermo, Robert E.; Katze, Michael G.
Title: Next-Generation Sequencing of Small RNAs from HIV-Infected Cells Identifies Phased microRNA Expression Patterns and Candidate Novel microRNAs Differentially Expressed upon Infection Document date: 2013_2_5
ID: t98g8z7i_41
Snippet: Functional analysis of mRNA targets of DE microRNAs. To examine annotations associated with target mRNAs, we utilized the NIH David resource (43) . We analyzed up-and downregulated target mRNAs separately in David using the Functional Annotation Chart feature with annotations for GO_BP_Fat, GO_MF_Fat, BioCarta, and KEGG_Pathway and human genome as background. An identical analysis was performed on up-and downregulated DE mRNAs from mRNA-Seq data......
Document: Functional analysis of mRNA targets of DE microRNAs. To examine annotations associated with target mRNAs, we utilized the NIH David resource (43) . We analyzed up-and downregulated target mRNAs separately in David using the Functional Annotation Chart feature with annotations for GO_BP_Fat, GO_MF_Fat, BioCarta, and KEGG_Pathway and human genome as background. An identical analysis was performed on up-and downregulated DE mRNAs from mRNA-Seq data. Overrepresentation of target mRNAs was determined by one-sided Fisher's exact tests for each annotation term.
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