Author: Willemsen, Anouk; Zwart, Mark P
Title: On the stability of sequences inserted into viral genomes Document date: 2019_11_14
ID: vv5gpldi_87
Snippet: It will certainly not always be possible to address issues of insert stability through demographic changes, but theory suggests this can be an interesting approach. Some experimental protocols already exploit some of these principles, in particular strict adherence to low MOI (Fitzgerald et al. 2006) . One should caution against naive applications of evolutionary theory, as the details of each real-world system matter (Schmerer et al. 2014 )......
Document: It will certainly not always be possible to address issues of insert stability through demographic changes, but theory suggests this can be an interesting approach. Some experimental protocols already exploit some of these principles, in particular strict adherence to low MOI (Fitzgerald et al. 2006) . One should caution against naive applications of evolutionary theory, as the details of each real-world system matter (Schmerer et al. 2014 ).
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