Author: Huang, Guohong; Yu, Deshan; Zhu, Zhen; Zhao, Hai; Wang, Peng; Gray, Gregory C.; Meng, Lei; Xu, Wenbo
Title: Outbreak of febrile respiratory illness associated with human adenovirus type 14p1 in Gansu Province, China Document date: 2013_5_22
ID: t74wq8ru_20
Snippet: Sequence analysis of the fiber gene from the HAdV-14p1 isolated in the United States, Europe, 30, 35 and China (Gansu2011-01 and 2 isolates in 2010) showed a 6-nt deletion resulting in a 2-amino acid (aa) deletion (i.e., lysine and glutamine) at positions 251 and 252 in the knob region with respect to the prototype strain HAdV-14p de Wit. 36 However, whether the deletion affects the pathogenicity and virulence of HAdV-14p1 requires further studie.....
Document: Sequence analysis of the fiber gene from the HAdV-14p1 isolated in the United States, Europe, 30, 35 and China (Gansu2011-01 and 2 isolates in 2010) showed a 6-nt deletion resulting in a 2-amino acid (aa) deletion (i.e., lysine and glutamine) at positions 251 and 252 in the knob region with respect to the prototype strain HAdV-14p de Wit. 36 However, whether the deletion affects the pathogenicity and virulence of HAdV-14p1 requires further studies. 37, 38 Although our study did not provide further evidence to explain whether the 2-aa deletion might alter the virulence and increase the pathogenicity of HAdV-14p1, it suggested that the strain HAdV-14p1 had been stable for the last decade and was likely co-circulating in Europe, the United States, and Asia.
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