Author: Park, Sun Hee; Kim, Yeon-Sook; Jung, Younghee; Choi, Soo young; Cho, Nam-Hyuk; Jeong, Hye Won; Heo, Jung Yeon; Yoon, Ji Hyun; Lee, Jacob; Cheon, Shinhye; Sohn, Kyung Mok
Title: Outbreaks of Middle East Respiratory Syndrome in Two Hospitals Initiated by a Single Patient in Daejeon, South Korea Document date: 2016_6_30
ID: soiimy63_38
Snippet: We observed heterogeneity in transmission in this Daejeon cluster as described in the previous epidemiologic studies [24, 25] . One secondary case infected only one patient among numerous contacts, whereas one index case generated 23 secondary cases. The disease stage of an infector was not the sole determinant for disease severity in infected individuals as one tertiary case who was infected by a secondary case on the day of symptom onset suffer.....
Document: We observed heterogeneity in transmission in this Daejeon cluster as described in the previous epidemiologic studies [24, 25] . One secondary case infected only one patient among numerous contacts, whereas one index case generated 23 secondary cases. The disease stage of an infector was not the sole determinant for disease severity in infected individuals as one tertiary case who was infected by a secondary case on the day of symptom onset suffered severe pneumonia requiring extracorporeal membrane oxygenation. Also, the disease severity was often unpredictable in that there were severe cases among those without comorbidities or those with the long incubation period. Studies on genetic predisposition and susceptibility of hosts may help provide a clue to such heterogeneities in MERS-CoV infection.
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