Selected article for: "acute fulminant hepatitis and liver failure"
Author: Parvez, Mohammad K.; Tabish Rehman, Md.; Alam, Perwez; Al-Dosari, Mohammed S.; Alqasoumi, Saleh I.; Alajmi, Mohammed F.
Title: Plant-derived antiviral drugs as novel hepatitis B virus inhibitors: Cell culture and molecular docking study
  • Document date: 2018_12_26
    • ID: xibqsjib_1
    Snippet: Hepatitis B virus (HBV) causes acute and chronic liver diseases, including fulminant liver failure, cirrhosis and hepatocellular carcinoma, affecting about two billion of world population (Teo and Locarnini, 2010) . Of these, an estimated 240 million individuals with chronic hepatitis B (CHB) live in high to moderate endemic regions in Asia, sub-Sharan Africa, Eastern Europe and Latin America (WHO, 2017) . HBV is the smallest known DNA virus with.....
    Document: Hepatitis B virus (HBV) causes acute and chronic liver diseases, including fulminant liver failure, cirrhosis and hepatocellular carcinoma, affecting about two billion of world population (Teo and Locarnini, 2010) . Of these, an estimated 240 million individuals with chronic hepatitis B (CHB) live in high to moderate endemic regions in Asia, sub-Sharan Africa, Eastern Europe and Latin America (WHO, 2017) . HBV is the smallest known DNA virus with a circular, double-stranded genome ($3.2 kb) having four overlapped open reading frames encoding surface or envelope (S), core (C), pre-core (pre-C/e), polymerase/reverse-transcriptase (Pol/RT) and X proteins (Beck and Nassal, 2007) . Very uniquely, HBV replicates its DNA via an RNA intermediate molecule through reversetranscription, and hence nicknamed 'pararetrovirus'.

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