Author: Parvez, Mohammad K.; Tabish Rehman, Md.; Alam, Perwez; Al-Dosari, Mohammed S.; Alqasoumi, Saleh I.; Alajmi, Mohammed F.
Title: Plant-derived antiviral drugs as novel hepatitis B virus inhibitors: Cell culture and molecular docking study Document date: 2018_12_26
ID: xibqsjib_70
Snippet: Plant b-sitosterol has been shown to exhibit in vitro and in vivo anti-HIV activity (Bouic, 1997) . Recently, antiviral effect of bsitosterol isolated from cottonseed oil against tobacco mosaic virus (TMV) is also reported . This is the first report showing the in vitro anti-HBV activity of b-sitosterol. This was further supported by our in silico analysis where b-sitosterol interacted with HBV Pol through Trp3, Pro4, Arg41, Leu42, Phe88, Tyr89, .....
Document: Plant b-sitosterol has been shown to exhibit in vitro and in vivo anti-HIV activity (Bouic, 1997) . Recently, antiviral effect of bsitosterol isolated from cottonseed oil against tobacco mosaic virus (TMV) is also reported . This is the first report showing the in vitro anti-HBV activity of b-sitosterol. This was further supported by our in silico analysis where b-sitosterol interacted with HBV Pol through Trp3, Pro4, Arg41, Leu42, Phe88, Tyr89, His160 and Met171 where the free energy of b-sitosterol-Pol complex was À8.3 kcal/mol.
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