Author: LI, Xunliang; LI, Pengchong; CAO, Liyan; BAI, Yunyun; CHEN, Huijie; LIU, He; REN, Xiaofeng; LI, Guangxing
Title: Porcine IL-12 plasmid as an adjuvant improves the cellular and humoral immune responses of DNA vaccine targeting transmissible gastroenteritis virus spike gene in a mouse model Document date: 2019_9_2
ID: rme6b022_28
Snippet: As shown in Fig. 2A , T lymphocyte proliferation was significantly upregulated at 14, 28, and 42 dpi in pVAX1-(TGEV-S1) and pVAX1-(TGEV-S1) plus pVAX1-(pIL-12) groups compared to that in the control groups (P<0.01). At 14 and 28 dpi, the pVAX1- (TGEV-S1) plus pVAX1-(pIL-12) group showed a significant upregulation in T lymphocyte proliferation level as compared with the groups treated with the other construct (P<0.01). The proliferation of spleen .....
Document: As shown in Fig. 2A , T lymphocyte proliferation was significantly upregulated at 14, 28, and 42 dpi in pVAX1-(TGEV-S1) and pVAX1-(TGEV-S1) plus pVAX1-(pIL-12) groups compared to that in the control groups (P<0.01). At 14 and 28 dpi, the pVAX1- (TGEV-S1) plus pVAX1-(pIL-12) group showed a significant upregulation in T lymphocyte proliferation level as compared with the groups treated with the other construct (P<0.01). The proliferation of spleen T lymphocytes is shown in Fig. 2B . At 28 dpi, the pVAX1-(TGEV-S1) plus pVAX1-(pIL-12) group showed much higher upregulation than any other groups (P<0.01). At 14 and 42 dpi, pVAX1-(TGEV-S1) group also showed a significant upregulation (P<0.01) in spleen T lymphocyte proliferation as compared to the control groups.
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