Selected article for: "adverse reaction and blood donor"
Author: Chun, Sejong; Chung, Chi Ryang; Ha, Young Eun; Han, Tae Hee; Ki, Chang-Seok; Kang, Eun-Suk; Park, Jin Kyeong; Peck, Kyong Ran; Cho, Duck
Title: Possible Transfusion-Related Acute Lung Injury Following Convalescent Plasma Transfusion in a Patient With Middle East Respiratory Syndrome
  • Document date: 2016_4_25
    • ID: tawmg6g6_3
    Snippet: The convalescent plasma donor was a cured 22-yr-old female patient. She had no previous history of gestation, and no record of transfusion was found. The donor's blood was screened for hemoglobin ( > 12.0 g/dL), hepatitis B virus, HIV, and hepatitis C virus by both serologic and nucleic acid testing (negative), for syphilis (negative) by serologic test, alanine aminotransferase ( < 65 IU), and MERS-CoV RNA (negative), and was without any other co.....
    Document: The convalescent plasma donor was a cured 22-yr-old female patient. She had no previous history of gestation, and no record of transfusion was found. The donor's blood was screened for hemoglobin ( > 12.0 g/dL), hepatitis B virus, HIV, and hepatitis C virus by both serologic and nucleic acid testing (negative), for syphilis (negative) by serologic test, alanine aminotransferase ( < 65 IU), and MERS-CoV RNA (negative), and was without any other contraindication for plasmapheresis donation other than a seven-day interval between donation and termination of treatment. The ABO/RhD blood type of the donor was identical to www.annlabmed.org http://dx.doi.org/10.3343/alm.2016.36.4.393 that of the patient. In addition, the donor was retrospectively tested for the presence of anti-HLA class I and II antibodies and anti-human neutrophil antigen (HNA) antibodies, which were all negative. On June 16, apheresis was performed, and 500 mL of plasma was collected without any adverse effects on the donor. The patient received 250 mL of the product immediately following plasma collection, and the remaining 250 mL was preserved, which was later discarded after the subsequent adverse reaction was observed in the recipient. The collected plasma was not pathogen-inactivated.

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