Author: Joseph R Fauver; Mary E. Petrone; Emma B Hodcroft; Kayoko Shioda; Hanna Y Ehrlich; Alexander G. Watts; Chantal B.F. Vogels; Anderson F. Brito; Tara Alpert; Anthony Muyombwe; Jafar Razeq; Randy Downing; Nagarjuna R. Cheemarla; Anne L Wyllie; Chaney C. Kalinich; Isabel Ott; Josh Quick; Nicholas J. Loman; Karla M. Neugebauer; Alexander L. Greninger; Keith R. Jerome; Pavitra Roychoundhury; Hong Xie; Lasata Shrestha; Meei-Li Huang; Virginia E. Pitzer; Akiko Iwasaki; Saad B. Omer; Kamran Khan; Isaac Bogoch; Richard A. Martinello; Ellen F. Foxman; Marie-Louise Landry; Richard A Neher; Albert I Ko; Nathan D. Grubaugh
Title: Coast-to-coast spread of SARS-CoV-2 in the United States revealed by genomic epidemiology Document date: 2020_3_26
ID: 8m06zdho_3
Snippet: Due to its proximity to several high-volume airports, southern Connecticut is a suitable location in which to test this hypothesis. By sequencing SARS-CoV-2 from local cases and comparing their relatedness to virus genome sequences from other locations, we used 'genomic epidemiology' (Grubaugh et al., 2019a) to identify the likely sources of SARS-CoV-2 in Connecticut. We supplemented our viral genomic analysis with airline travel data from major .....
Document: Due to its proximity to several high-volume airports, southern Connecticut is a suitable location in which to test this hypothesis. By sequencing SARS-CoV-2 from local cases and comparing their relatedness to virus genome sequences from other locations, we used 'genomic epidemiology' (Grubaugh et al., 2019a) to identify the likely sources of SARS-CoV-2 in Connecticut. We supplemented our viral genomic analysis with airline travel data from major airports in southern New England to estimate the risk of domestic and international importation therein. Our data suggest that the risk of domestic importation of SARS-CoV-2 into this region far outweighs that of international introductions regardless of federal travel restrictions, and find evidence for coast-to-coast U.S. SARS-CoV-2 spread.
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