Author: Dejnirattisai, Wanwisa; Webb, Andrew I.; Chan, Vera; Jumnainsong, Amonrat; Davidson, Andrew; Mongkolsapaya, Juthathip; Screaton, Gavin
Title: Lectin Switching During Dengue Virus Infection Document date: 2011_6_15
ID: qos9vu3r_26
Snippet: Previous reports with dengue virus have suggested that the virus shows equal tropism for both DC-SIGN and L-SIGN. These reports were from virus produced in tumor cell lines and not from primary cells. We tested the infectivity of virus produced in Vero cells, and in agreement with these previous reports dengue produced in this tumor cell line was able to efficiently infect 3T3 cells via either DC-SIGN or L-SIGN ( Figure 3C ). Finally, we tested t.....
Document: Previous reports with dengue virus have suggested that the virus shows equal tropism for both DC-SIGN and L-SIGN. These reports were from virus produced in tumor cell lines and not from primary cells. We tested the infectivity of virus produced in Vero cells, and in agreement with these previous reports dengue produced in this tumor cell line was able to efficiently infect 3T3 cells via either DC-SIGN or L-SIGN ( Figure 3C ). Finally, we tested the binding of insect-and DC-produced virus to the 3T3 transfectants ( Figure 3D ). In agreement with the DC binding experiments DC-produced virus was unable to bind to DC-SIGN-expressing DCs, whereas both insect-and DC-derived viruses could bind to L-SIGNexpressing cells.
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