Author: Dejnirattisai, Wanwisa; Webb, Andrew I.; Chan, Vera; Jumnainsong, Amonrat; Davidson, Andrew; Mongkolsapaya, Juthathip; Screaton, Gavin
Title: Lectin Switching During Dengue Virus Infection Document date: 2011_6_15
ID: qos9vu3r_41
Snippet: The difference in the binding specificities of dengue viruses produced in Vero versus primary dendritic cells was somewhat surprising and likely related to the expression of high-mannose moieties in Vero. A number of tumor cell lines express high-mannose sugars, and we have previously described the generation of a monoclonal antibody that recognizes a variety of tumor cell types and which binds to high-mannose moieties [38] . The differential aff.....
Document: The difference in the binding specificities of dengue viruses produced in Vero versus primary dendritic cells was somewhat surprising and likely related to the expression of high-mannose moieties in Vero. A number of tumor cell lines express high-mannose sugars, and we have previously described the generation of a monoclonal antibody that recognizes a variety of tumor cell types and which binds to high-mannose moieties [38] . The differential affinity of DC-SIGN for ligands expressed by tumor cell lines versus primary cells has been observed before and led some to speculate that DC-SIGN may participate in tumor surveillance [39] . There appears to be a further added level of complexity as the glycosylation profiles may vary in a given cell line depending on the exact position of the N-linked site within the polypeptide chain [29] .
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