Protocol for a randomised, single-blind, two-arm, parallel-group controlled trial of the efficacy of rhinothermy delivered by nasal high flow therapy in the treatment of the common cold

Bird, Grace; Braithwaite, Irene; Harper, James; McKinstry, Steven; Koorevaar, Iris; Fingleton, James; Semprini, Alex; Dilcher, Meik; Jennings, Lance; Weatherall, Mark; Beasley, Richard

We will show you how to complete your online symptom diary to: ï‚· Record any medications taken (cold and flu remedies or paracetamol etc.) each day for the next 13 days ï‚· Record each of your common cold symptoms daily for the next 13 days 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 F o r p e e r r e v i e w o n l y We will randomise you to one of two possible rhinothermy treatment regimens which deliver rhinothermy at different settings. The chance of you being on either treatment is 50%, like tossing a coin. We will show you how to use your rhinothermy device here today and at home for the next 4 days. You will also receive your first (Day 1) treatment here today.