Author: Yan, Fang; Zhao, Yujun; Hu, Yongting; Qiu, Jianyang; Lei, Wenxin; Ji, Wenhui; Li, Xuying; Wu, Qian; Shi, Xiumin; Li, Zhong
Title: Protection of chickens against infectious bronchitis virus with a multivalent DNA vaccine and boosting with an inactivated vaccine Document date: 2013_3_24
ID: wwuqxx1r_28
Snippet: Our results directly demonstrated that the multivalent DNA vaccine targeting the S1, M, and N proteins of IBV developed humoral and cellular immune responses against IBV in chickens. We also showed that our prime-boost immunization strategy induced strong immune responses and provided effective protection from challenge with a high dose of virulent IBV. DNA vaccines are easy to prepare and inactivated vaccines are readily available. Administratio.....
Document: Our results directly demonstrated that the multivalent DNA vaccine targeting the S1, M, and N proteins of IBV developed humoral and cellular immune responses against IBV in chickens. We also showed that our prime-boost immunization strategy induced strong immune responses and provided effective protection from challenge with a high dose of virulent IBV. DNA vaccines are easy to prepare and inactivated vaccines are readily available. Administration of DNA vaccines with an inactivated vaccine is a safe and effective immunization technique. Given its superior efficacy, this combination represents a valuable strategy for protecting against IBV infection and can combat poor cross-protection among the numerous IBV serotypes along with the frequent emergence of new variants.
Search related documents:
Co phrase search for related documents- cross protection and effective protection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- cross protection and frequent emergence: 1, 2
- cross protection and high dose: 1, 2, 3, 4, 5, 6
- cross protection and IBV immune response: 1, 2
- cross protection and IBV infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- cross protection and IBV serotype: 1, 2, 3, 4, 5, 6
- cross protection and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37
- cross protection and inactivated vaccine: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- cross protection and multivalent dna: 1
- cross protection and multivalent dna vaccine: 1
- cross protection and new variant: 1, 2, 3, 4, 5, 6
- cross protection and new variant frequent emergence: 1
- cross protection and poor cross protection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- cross protection and prime boost: 1, 2, 3, 4, 5
- cross protection and strong immune response: 1, 2, 3
- dna vaccine and effective protection: 1, 2, 3, 4, 5, 6, 7, 8, 9
- dna vaccine and high dose: 1, 2, 3, 4, 5
- dna vaccine and IBV immune response: 1
- dna vaccine and IBV infection: 1, 2
Co phrase search for related documents, hyperlinks ordered by date