Author: Cao, Rui-Yuan; Xu, Yong-fen; Zhang, Tian-Hong; Yang, Jing-Jing; Yuan, Ye; Hao, Pei; Shi, Yi; Zhong, Jin; Zhong, Wu
Title: Pediatric Drug Nitazoxanide: A Potential Choice for Control of Zika Document date: 2017_2_3
ID: sbf9qi6g_21
Snippet: To explore the antiviral mechanism of these 2 drugs, we first investigated whether they affect the viral attachment stage by treating the Vero cells at 4°C with drugs and the ZIKV (Figure 2A ). At 4°C, the viral particles can physically bind to the cell surface without endocytosis, which occurs most efficiently at 37°C. After washing to remove the unadsorbed ZIKV, the cells were harvested for ZIKV RNA detection. Our results showed that these 2.....
Document: To explore the antiviral mechanism of these 2 drugs, we first investigated whether they affect the viral attachment stage by treating the Vero cells at 4°C with drugs and the ZIKV (Figure 2A ). At 4°C, the viral particles can physically bind to the cell surface without endocytosis, which occurs most efficiently at 37°C. After washing to remove the unadsorbed ZIKV, the cells were harvested for ZIKV RNA detection. Our results showed that these 2 drugs did not inhibit the attachment of ZIKV to the cells.
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