Author: Chew, Miaw-Fang; Poh, Keat-Seong; Poh, Chit-Laa
Title: Peptides as Therapeutic Agents for Dengue Virus Document date: 2017_10_15
ID: u1opdwmd_17
Snippet: Although studies demonstrated that DENV mainly enters host cells via receptor initiated-clathrin mediated endocytosis [102] [103] [104] , viral entry via clathrin-independent endocytic route has also been observed [104] . In addition, evidence of direct entry via fusion with plasmatic membrane leading to direct penetration into cytoplasm without undergoing endocytosis has also been described [105, 106] . Furthermore, evidence showed that DENV is .....
Document: Although studies demonstrated that DENV mainly enters host cells via receptor initiated-clathrin mediated endocytosis [102] [103] [104] , viral entry via clathrin-independent endocytic route has also been observed [104] . In addition, evidence of direct entry via fusion with plasmatic membrane leading to direct penetration into cytoplasm without undergoing endocytosis has also been described [105, 106] . Furthermore, evidence showed that DENV is able to infect a variety of cell types, including those isolated from humans [107, 108] , monkeys [92, 93] , hamsters [95, 109] and mosquitoes [110, 111] via different receptors. Therefore, the DENV entry pathway is greatly dependent on the cell type and viral strain. Due to the variability in viral entry routes and broad tissue tropism, targeting the viral structural proteins is easier than the vastly different cellular receptors, as DENV possesses the capability to utilize a wide range of cellular receptors and pathways to enter host cells. Viral structural proteins, especially the E protein, is therefore a popular target for antiviral inhibitors to interfere with the virus-host interactions and stop subsequent viral entry.
Search related documents:
Co phrase search for related documents- cell type and direct entry: 1, 2, 3
- cell type and endocytic route: 1
- cell type and entry pathway: 1, 2, 3, 4, 5, 6, 7, 8
- cell type and entry route: 1, 2
- cell type and host cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75
- cell type and host cell enter: 1, 2, 3
- cell type and mediate endocytosis: 1
- cell type and structural protein: 1, 2, 3, 4, 5, 6, 7
- cell type and tissue tropism: 1, 2, 3, 4, 5, 6, 7, 8
- cell type and viral entry: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
- cell type and viral strain: 1, 2
- cell type and viral strain cell type: 1, 2
- cell type and viral structural protein: 1
- cell type and virus host: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58
- cell type and virus host interaction: 1, 2, 3
- cell type and wide range: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- cell type variety and different receptor: 1
- cell type variety and host cell: 1
- cell type variety and wide range: 1
Co phrase search for related documents, hyperlinks ordered by date