Author: Chew, Miaw-Fang; Poh, Keat-Seong; Poh, Chit-Laa
Title: Peptides as Therapeutic Agents for Dengue Virus Document date: 2017_10_15
ID: u1opdwmd_8
Snippet: Peptides are biologically active molecules comprising the combination of at least two amino acids through a peptide bond. In contrast to large proteins, they are smaller in size and are considered to contain less than 100 amino acid residues. Peptides are known to have attractive pharmacological profiles due to their highly selective and relatively safe characteristics [27] . They readily exist in the human body and exert diverse biological roles.....
Document: Peptides are biologically active molecules comprising the combination of at least two amino acids through a peptide bond. In contrast to large proteins, they are smaller in size and are considered to contain less than 100 amino acid residues. Peptides are known to have attractive pharmacological profiles due to their highly selective and relatively safe characteristics [27] . They readily exist in the human body and exert diverse biological roles, predominantly as signalling and regulatory molecules in a variety of physiological processes [51] . In the past, peptides were held back in the drug development pipelines due to their instability, whereby they could be easily degraded by at least 569 proteases in the human body [52] . Nevertheless, a number of technological breakthroughs and advancements have reversed the situation. This has resulted in the spark of interest in peptide drug development. Current technologies have allowed the modification of peptides to create artificial variants with improved stability and overcome pharmacodynamic weaknesses.
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