Author: Vineet D. Menachery; Lisa E. Gralinski; Hugh D. Mitchell; Kenneth H. Dinnon; Sarah R. Leist; Boyd L. Yount; Eileen T. McAnarney; Rachel L. Graham; Katrina M. Waters; Ralph S. Baric
Title: Combination attenuation offers strategy for live-attenuated coronavirus vaccines Document date: 2018_4_28
ID: 3t75dbb7_1
Snippet: Emergent coronaviruses remain a significant threat to global public health and rapid response 23 vaccine platforms are needed to stem future outbreaks. However, failure of many previous CoV 24 vaccine formulations has clearly highlighted the need to test efficacy under different conditions 25 and especially in vulnerable populations like the aged and immune-compromised. This study 26 illustrates that despite success in young models, the NSP16 mut.....
Document: Emergent coronaviruses remain a significant threat to global public health and rapid response 23 vaccine platforms are needed to stem future outbreaks. However, failure of many previous CoV 24 vaccine formulations has clearly highlighted the need to test efficacy under different conditions 25 and especially in vulnerable populations like the aged and immune-compromised. This study 26 illustrates that despite success in young models, the NSP16 mutant carries too much risk for 27 pathogenesis and reversion in vulnerable models to be used as a stand-alone vaccine strategy.
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