Author: Parvez, Mohammad K.; Tabish Rehman, Md.; Alam, Perwez; Al-Dosari, Mohammed S.; Alqasoumi, Saleh I.; Alajmi, Mohammed F.
Title: Plant-derived antiviral drugs as novel hepatitis B virus inhibitors: Cell culture and molecular docking study Document date: 2018_12_26
ID: xibqsjib_66
Snippet: Baccatin III is isolated from the needles of the Pacific yew tree, and synthetically available as 10-deacetylbaccatin III. Baccatin III is widely assumed to be an inactive derivative of taxol, isolated from Taxus brevifolia bark. Though in a single in vitro study, Baccarin III has shown anti-HSV activity at non-cytotoxic dose (Krawczyk et al., 2005) ; its mechanism of action is not known. In conformity, our results, for the first time, showed a h.....
Document: Baccatin III is isolated from the needles of the Pacific yew tree, and synthetically available as 10-deacetylbaccatin III. Baccatin III is widely assumed to be an inactive derivative of taxol, isolated from Taxus brevifolia bark. Though in a single in vitro study, Baccarin III has shown anti-HSV activity at non-cytotoxic dose (Krawczyk et al., 2005) ; its mechanism of action is not known. In conformity, our results, for the first time, showed a high anti-HBV activity of baccatin III. Docking of baccatin III with HBV pol showed the interaction through Asn33, Asn36, Asp83, Lys241, Asn248 and Met250 residues that formed the baccatin-Pol complex with a free energy of À7.0 kcal/mol. Notably, Asp205 and Asp206 of the 'YMDD' motif was among the baccatin III surrounding amino acids.
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