Author: Rybicki, Edward Peter
Title: Plant-made vaccines and reagents for the One Health initiative Document date: 2017_8_28
ID: wupictvw_23
Snippet: A potentially therapeutic product for treatment of dengue infections is the mAb E60, which neutralizes all 4 serotypes of the virus: 49 a problem with production in mammalian cells, however, is that the mAb exhibits ADE, meaning treated animals are more susceptible to severe disease if infected with another serotype. Production of the mAb by agroinfiltrationmediated transient expression in N benthamiana, however, abrogated ADE activity without af.....
Document: A potentially therapeutic product for treatment of dengue infections is the mAb E60, which neutralizes all 4 serotypes of the virus: 49 a problem with production in mammalian cells, however, is that the mAb exhibits ADE, meaning treated animals are more susceptible to severe disease if infected with another serotype. Production of the mAb by agroinfiltrationmediated transient expression in N benthamiana, however, abrogated ADE activity without affecting antigen binding and neutralisation efficiency against DENV serotypes 2 and 4, presumably due to the different N-glycosylation pattern compared with the conventional mAb. This property could be exploited for other therapeutic MAbs, where modulation or reduction of Fc-mediated functions may be advantageous.
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