Author: LI, Xunliang; LI, Pengchong; CAO, Liyan; BAI, Yunyun; CHEN, Huijie; LIU, He; REN, Xiaofeng; LI, Guangxing
Title: Porcine IL-12 plasmid as an adjuvant improves the cellular and humoral immune responses of DNA vaccine targeting transmissible gastroenteritis virus spike gene in a mouse model Document date: 2019_9_2
ID: rme6b022_5
Snippet: Eukaryotic expression plasmids are able to induce a robust immune response via endocytosis and antigen-presenting cells [14] . DNA vaccines offer advantages, as they contain no actual infectious agents, can be easily transported, and may induce effective cellular and humoral immune responses. Therefore, nucleic acid vaccines could serve as effective alternatives for diseases control. Several reports have suggested the addition of a cytokine as an.....
Document: Eukaryotic expression plasmids are able to induce a robust immune response via endocytosis and antigen-presenting cells [14] . DNA vaccines offer advantages, as they contain no actual infectious agents, can be easily transported, and may induce effective cellular and humoral immune responses. Therefore, nucleic acid vaccines could serve as effective alternatives for diseases control. Several reports have suggested the addition of a cytokine as an adjuvant to increase vaccine efficacy. Interleukin (IL)-12 shows a central function in initiating and regulating cellular immune responses, and many studies have analyzed the use of IL-12 as a potential vaccine adjuvant [2, 17] .
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