Selected article for: "cell death and induce cell death"
Author: Wojciechowska, Marzena; Olejniczak, Marta; Galka-Marciniak, Paulina; Jazurek, Magdalena; Krzyzosiak, Wlodzimierz J.
Title: RAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disorders
  • Document date: 2014_10_29
    • ID: utigp2vi_22
    Snippet: A very recent study demonstrated that synthetic (GlyArg) 20 and (ProArg) 20 dipeptides encoded by sense and antisense C9ORF72 repeats, respectively, are toxic to cells. These dipeptides have ability to enter cells, migrate to nucleus, bind to nucleoli and induce cell death. The ProArg dipeptide toxicity manifests in aberrant pre-mRNA splicing similar to that observed in ALS patients, and in alteration of ribosomal RNA biogenesis (39) ......
    Document: A very recent study demonstrated that synthetic (GlyArg) 20 and (ProArg) 20 dipeptides encoded by sense and antisense C9ORF72 repeats, respectively, are toxic to cells. These dipeptides have ability to enter cells, migrate to nucleus, bind to nucleoli and induce cell death. The ProArg dipeptide toxicity manifests in aberrant pre-mRNA splicing similar to that observed in ALS patients, and in alteration of ribosomal RNA biogenesis (39) .

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