Author: Tan, Zhaoli; Gao, Lihua; Wang, Yan; Yin, Huihui; Xi, Yongyi; Wu, Xiaojie; Shao, Yong; Qiu, Weiyi; Du, Peng; Shen, Wenlong; Fu, Ling; Jia, Ru; Zhao, Chuanhua; Zhang, Yun; Zhao, Zhihu; Sun, Zhiwei; Chen, Hongxing; Hu, Xianwen; Xu, Jianming; Wang, Youliang
Title: PRSS contributes to cetuximab resistance in colorectal cancer Document date: 2020_1_1
ID: tymoeyoo_44
Snippet: To our knowledge, this is the first study to suggest that serum PRSS1 expression levels can be used as a prognostic biomarker of CRC and as a potential predictive biomarker in patients with mCRC receiving cetuximab treatment. In conclusion, our findings provide a rationale for the development of a PRSS1 inhibitor or anti-PRSS1 mAbs for the treatment of cancer or other diseases. Alternatively, mAb modification targeting cleavage sites may increase.....
Document: To our knowledge, this is the first study to suggest that serum PRSS1 expression levels can be used as a prognostic biomarker of CRC and as a potential predictive biomarker in patients with mCRC receiving cetuximab treatment. In conclusion, our findings provide a rationale for the development of a PRSS1 inhibitor or anti-PRSS1 mAbs for the treatment of cancer or other diseases. Alternatively, mAb modification targeting cleavage sites may increase the response to mAbs and benefit more patients. Our work may facilitate noninvasive monitoring of cetuximab treatment in patients with mCRC, although a large, blinded independent study will be needed to further determine the true clinical potential of PRSS1.
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