Selected article for: "expression profile and gene expression"
Author: Tan, Zhaoli; Gao, Lihua; Wang, Yan; Yin, Huihui; Xi, Yongyi; Wu, Xiaojie; Shao, Yong; Qiu, Weiyi; Du, Peng; Shen, Wenlong; Fu, Ling; Jia, Ru; Zhao, Chuanhua; Zhang, Yun; Zhao, Zhihu; Sun, Zhiwei; Chen, Hongxing; Hu, Xianwen; Xu, Jianming; Wang, Youliang
Title: PRSS contributes to cetuximab resistance in colorectal cancer
  • Document date: 2020_1_1
    • ID: tymoeyoo_6
    Snippet: By downloading and analyzing a comparative whole-genome expression profile established on Affymetrix 133A Microarrays via the BROAD Institute (www.broadinstitute.org/cgi-bin/cancer/datasets.cgi), we found through a wide literature search that 49 of 798 cell lines in the database were either cetuximab resistant or cetuximab sensitive. Through systematic comparison of the gene expression data of these cell lines, we determined that the expression o.....
    Document: By downloading and analyzing a comparative whole-genome expression profile established on Affymetrix 133A Microarrays via the BROAD Institute (www.broadinstitute.org/cgi-bin/cancer/datasets.cgi), we found through a wide literature search that 49 of 798 cell lines in the database were either cetuximab resistant or cetuximab sensitive. Through systematic comparison of the gene expression data of these cell lines, we determined that the expression of PRSS family genes (including PRSS1, PRSS2, and PRSS3) was higher in the cetuximabresistant cell lines than that in the cetuximab-sensitive cell lines ( Fig. 1A and table S1). Accordingly, we hypothesized that PRSS genes may contribute to cetuximab resistance.

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