Advancing a multivalent ‘Pan-anthelmintic’ vaccine against soil-transmitted nematode infections

Zhan, Bin; Beaumier, Coreen M; Briggs, Neima; Jones, Kathryn M; Keegan, Brian P; Bottazzi, Maria Elena; Hotez, Peter J

Advancing a multivalent 'Pan-anthelmintic' vaccine against soil-transmitted nematode infections Review informahealthcare.com . For ascariasis, the six identified antigens listed in TABLE 2 will be targeted based on the previous evidence that they can reproduce some of the protective immunity afforded by living UV-attenuated eggs [22, 23, [39] [40] [41] [42] [43] [44] [45] [46] [47] [48] . Some of these antigens are expressed in both larval stage and adult worms. In parallel, a proteomics approach will be advanced to identify additional ES and possibly surface antigens. . For trichuriasis, antigens from the stichosome will be emphasized given the immunological protection afforded by extracts of this organ, which is a rich source of antigens from adult worms embedded in the colonic mucosa [52, 56, 59, 60] . Some of these stichocyte/stichosome antigens may also be related to previously discovered T. sprialis antigens [15, 61, [63] [64] [65] [66] [67] [68] [69] 83, 84] .