Author: Kent, A. C. C.; Cross, G.; Taylor, D. R.; Sherwood, R. A.; Watson, P. J.
Title: Measurement of serum 7a-hydroxy-4-cholesten-3-one as a marker of bile acid malabsorption in dogs with chronic diarrhoea: a pilot study Document date: 2016_4_6
ID: rkdfde07_25
Snippet: In addition to being underpowered, the retrospective nature of this study did not allow a comparison of serum C4 measurement to the gold standard of SeHCAT. It was therefore not possible to confirm that serum C4 elevations indicate malabsorption of bile acids. It is possible that serum C4 was elevated by an alternative mechanism in these patients. However, this pilot study suggests that this is a worthwhile area to investigate further. Second, ac.....
Document: In addition to being underpowered, the retrospective nature of this study did not allow a comparison of serum C4 measurement to the gold standard of SeHCAT. It was therefore not possible to confirm that serum C4 elevations indicate malabsorption of bile acids. It is possible that serum C4 was elevated by an alternative mechanism in these patients. However, this pilot study suggests that this is a worthwhile area to investigate further. Second, accurate clinical follow-up on cases was restricted and cases with abnormal C4 concentrations were not able to be assessed for response to specific therapy. Lastly, it would have been interesting to measure serum cobalamin for the control cases as well as the clinical cases; however, as the samples came from residual archived blood, insufficient volumes were available to measure both parameters.
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