Author: Vere Hodge, R Anthony
Title: Meeting report: 30th International Conference on Antiviral Research, in Atlanta, GA, USA Document date: 2018_6_28
ID: tudwns0r_99
Snippet: Mark Pallansch described the need for an effective anti-poliovirus compounds and to the ongoing work investigating resistance to pocapavir (V-073, capsid inhibitor, preventing viral RNA release) and V-7404 (3C PI). The greatest medical need is to treat those SCID patients in whom poliovirus infection has continued for many years. Experience with other longlasting chronic infections indicates that drug therapy requires a combination of drugs, whic.....
Document: Mark Pallansch described the need for an effective anti-poliovirus compounds and to the ongoing work investigating resistance to pocapavir (V-073, capsid inhibitor, preventing viral RNA release) and V-7404 (3C PI). The greatest medical need is to treat those SCID patients in whom poliovirus infection has continued for many years. Experience with other longlasting chronic infections indicates that drug therapy requires a combination of drugs, which includes at least one nucleoside/tide inhibitor with a high genetic barrier to resistance. Therefore, it may be timely to prepare a 'plan B', approaching companies with a good panel of nucleoside/tide compounds.
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