Author: Wojciechowska, Marzena; Olejniczak, Marta; Galka-Marciniak, Paulina; Jazurek, Magdalena; Krzyzosiak, Wlodzimierz J.
Title: RAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disorders Document date: 2014_10_29
ID: utigp2vi_42
Snippet: It has been reported that the expression of transcripts harboring expanded CUG, CCUG, CAG and G 4 C 2 repeats can cause cellular stress conditions mediated through the inhibition of protein translation, as demonstrated in DM1 and DM2 (71, 72) , and by triggering nucleolar stress, as shown in SCA3, HD and C9ALS/FTD (76) (77) (78) . Such stress conditions could affect the post-translational modification of proteins involved in translation initiatio.....
Document: It has been reported that the expression of transcripts harboring expanded CUG, CCUG, CAG and G 4 C 2 repeats can cause cellular stress conditions mediated through the inhibition of protein translation, as demonstrated in DM1 and DM2 (71, 72) , and by triggering nucleolar stress, as shown in SCA3, HD and C9ALS/FTD (76) (77) (78) . Such stress conditions could affect the post-translational modification of proteins involved in translation initiation, leading to faulty functioning, which is then reflected in altered RNA-binding affinity that can trigger RAN protein synthesis.
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