Author: Jefferies, Sarah; Braithwaite, Irene; Walker, Steven; Weatherall, Mark; Jennings, Lance; Luck, Michelle; Barrett, Kevin; Siebers, Robert; Blackmore, Timothy; Beasley, Richard; Perrin, Kyle
Title: Randomized controlled trial of the effect of regular paracetamol on influenza infection Document date: 2015_12_6
ID: vj3m50sb_16
Snippet: Past research reports the standard deviation (SD) for AUC for quantitative PCR influenza viral load for Days 1-5 between 1.4 and 2.2 log10 units. 26 We used the mean of these SDs for our analysis. A randomized controlled trial of anti-viral therapy in influenza reports a difference from placebo therapy of 2.2 log10 units, 27 and we anticipated that the effect of paracetamol may be half the difference found with anti-viral therapy, (1.1). A total .....
Document: Past research reports the standard deviation (SD) for AUC for quantitative PCR influenza viral load for Days 1-5 between 1.4 and 2.2 log10 units. 26 We used the mean of these SDs for our analysis. A randomized controlled trial of anti-viral therapy in influenza reports a difference from placebo therapy of 2.2 log10 units, 27 and we anticipated that the effect of paracetamol may be half the difference found with anti-viral therapy, (1.1). A total sample size of 80, with 40 in each of the two treatment arms, had 80% power to detect this difference, with a type I error rate of 5%.
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