Montelukast Reduces Serum Levels of Eosinophil-Derived Neurotoxin in Preschool Asthma

Kim, Chang-Keun; Callaway, Zak; Park, Jin-Sung; Nishimori, Hisashi; Ogino, Tikatoshi; Nagao, Mizuho; Fujisawa, Takao

Primary outcome was the number of asthma control days (ACD). An ACD was defined as a day with no beta-agonist rescue use; use of oral corticosteroids for asthma; daytime symptoms; nighttime awakenings; unscheduled health care visits, emergency department visits, or hospitalizations for asthma; or school absenteeism for asthma. ACD in both groups (BIS and MONT) were compared in 2 ways: 1) within group analyses comparing ACD at the beginning of the treatment period (0 week) to ACD at the other 3-time points (4, 8 and 12 weeks); and 2) between group analyses comparing ACD in each group at each time point (e.g., BIS ACD at 0 week versus MONT ACD at 0 week). An ACD value was calculated for each group during each time period. For example, ACD at 0 week was calculated during the 2-week run-in period (i.e., −2 to 0 week), ACD at 4 weeks was calculated during the time period from 0 to 4 weeks, etc. The first comparison used 2-way analysis of variance (ANOVA), followed by Sidak's multiple comparisons test. The second comparison used the Wilcoxon matched-pairs signed rank test.