Author: Sato, Hiroki; Yoneda, Misako; Honda, Tomoyuki; Kai, Chieko
Title: Morbillivirus Receptors and Tropism: Multiple Pathways for Infection Document date: 2012_3_1
ID: xic32wxh_24
Snippet: Signaling lymphocyte activation molecule is also known as CD150 and is expressed on thymocytes, activated lymphocytes, mature dendritic cells, macrophages, and platelets in humans and mice (Sidorenko and Clark, 1993; Cocks et al., 1995; Aversa et al., 1997) . In humans, CD14 + monocytes in tonsils and spleens express SLAM (Farina et al., 2004) . SLAM is implicated in the regulation of T-cell activation by affecting T-cell antigen receptor signali.....
Document: Signaling lymphocyte activation molecule is also known as CD150 and is expressed on thymocytes, activated lymphocytes, mature dendritic cells, macrophages, and platelets in humans and mice (Sidorenko and Clark, 1993; Cocks et al., 1995; Aversa et al., 1997) . In humans, CD14 + monocytes in tonsils and spleens express SLAM (Farina et al., 2004) . SLAM is implicated in the regulation of T-cell activation by affecting T-cell antigen receptor signaling. In addition, SLAM has the ability to regulate the functions of several other immune cell types, including natural killer and dendritic cells. Hence, SLAM has a broad involvement in the modulation of innate and acquired immune responses (Veillette and Latour, 2003; Veillette et al., 2007; Schwartzberg et al., 2009) .
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