Research Communications of the 27(th) ECVIM-CA Congress: Intercontinental, Saint Julian's, Malta, 14th to 16th September 2017

The FeMV+ were outdoor domestic shorthaired cats, 8 neutered males, 6 females (5/6 spayed), median age was 35 months (range 14-101 A significant increase in UPC was observed in FeMV+ (median 0.19, range 0.08-1.03) when compared to healthy subjects (median 0.10, range 0.04-0.40, P < 0.0003), while statistical differences were not detected between infected cats and CKD cats (median 0.23, range 0.10-0.80). In FeMV+, SDS-PAGE qualitative proteinuria showed differences if compared to the healthy cats. In particular, a tubular pattern was evidenced, with a decrease of uromodulin and an increase in the number and intensity of low molecular weight proteins, indicating a renal involvement, although less severe than in CKD cats. Renal pathology showed tubulo-interstitial nephritis and positive immunohistochemical stain for FeMV-N protein in tubular cells.