Title: Research Communications of the 27(th) ECVIM-CA Congress: Intercontinental, Saint Julian's, Malta, 14th to 16th September 2017 Document date: 2017_11_7
ID: roslkxeq_331
Snippet: Disclosures: No disclosures to report. The gold standard for determining causality in EBV-associated lymphomas is the detection of viral transcripts expressed during latency that promote uncontrolled growth. The aim of this study was to investigate FcaGHV1 gene expression in FIV-associated lymphoma. We targeted 3 FcaGHV1 open reading frames (ORFs). Two were identified by comparative sequence analyses; ORF73, a homologue of EBNA1 which is expresse.....
Document: Disclosures: No disclosures to report. The gold standard for determining causality in EBV-associated lymphomas is the detection of viral transcripts expressed during latency that promote uncontrolled growth. The aim of this study was to investigate FcaGHV1 gene expression in FIV-associated lymphoma. We targeted 3 FcaGHV1 open reading frames (ORFs). Two were identified by comparative sequence analyses; ORF73, a homologue of EBNA1 which is expressed in all EBV-associated malignancies and F7, a homologue of KSHV vFLIP, which encodes an anti-apoptotic protein. The third, ORF50, was identified during our RNA-Seq analyses of feline lymphoma transcriptome. Its homologue is a KSHV lytic cycle activator.
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