Selected article for: "AUG codon and initiation codon"
Author: Wojciechowska, Marzena; Olejniczak, Marta; Galka-Marciniak, Paulina; Jazurek, Magdalena; Krzyzosiak, Wlodzimierz J.
Title: RAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disorders
  • Document date: 2014_10_29
    • ID: utigp2vi_8
    Snippet: In deciphering an ambiguous pathomechanism of SCA8, the Ranum group has found that microsatellite expansions of CAG repeats can express homopolymeric proteins in all three reading frames in the absence of an AUG initiation codon (14) . This discovery, called Repeat-Associated Non-AUG translation or RAN translation, instigated a series of further findings from other laboratories that have proven that atypical protein production can be found in the.....
    Document: In deciphering an ambiguous pathomechanism of SCA8, the Ranum group has found that microsatellite expansions of CAG repeats can express homopolymeric proteins in all three reading frames in the absence of an AUG initiation codon (14) . This discovery, called Repeat-Associated Non-AUG translation or RAN translation, instigated a series of further findings from other laboratories that have proven that atypical protein production can be found in the presence of CGG repeats of FXTAS (16) as well as of G 4 C 2 and C 4 G 2 repeats of ALS/FTD (15, (17) (18) (19) (20) (21) (22) 31, 32) .

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