Author: Jefferies, Sarah; Braithwaite, Irene; Walker, Steven; Weatherall, Mark; Jennings, Lance; Luck, Michelle; Barrett, Kevin; Siebers, Robert; Blackmore, Timothy; Beasley, Richard; Perrin, Kyle
Title: Randomized controlled trial of the effect of regular paracetamol on influenza infection Document date: 2015_12_6
ID: vj3m50sb_1
Snippet: Seasonal and pandemic influenza infection is an important public health issue. 1, 2 Effective strategies to reduce the morbidity and mortality associated with influenza are a global health priority. 3 International guidelines recommend fever treatment with antipyretics during influenza infection with the qualification that they 'may help and are unlikely to cause harm'. 4 However fever is a beneficial adaptive physiological response to infection .....
Document: Seasonal and pandemic influenza infection is an important public health issue. 1, 2 Effective strategies to reduce the morbidity and mortality associated with influenza are a global health priority. 3 International guidelines recommend fever treatment with antipyretics during influenza infection with the qualification that they 'may help and are unlikely to cause harm'. 4 However fever is a beneficial adaptive physiological response to infection that may confer a survival benefit so that, in fact, treating fever with anti-pyretics could be harmful. 5 In animals, treatment with anti-pyretic drugs increases mortality in viral, 6 bacterial 7 and parasitic 8 infections. A meta-analysis of the effect of anti-pyretic drug therapy in animal models of influenza infection found an increased risk of mortality, with an odds ratio of 1.34 (95% CI: 1.04-1.73). 9 In humans paracetamol prolongs infection in varicella zoster, 10 malaria 11 and rhinovirus, 12 and impairs immune responses. 12, 13 There have been no previous randomized, doubleblind, placebo-controlled trials of the effect of antipyretic therapy on human influenza infection.
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