Author: Maddalena Dilucca; Athanasia Pavlopoulou; Sergio Forcelloni; ANDREA GIANSANTI; Alexandros G Georgakilas
Title: Codon usage and evolutionary rates of the 2019-nCoV genes Document date: 2020_3_27
ID: l9vtsj3e_7
Snippet: Genes M and E show quite low slopes, indicating that these proteins tend to evolve slowly by 165 accumulating nucleotide mutations on their genes. Conversely, the steeper slopes for genes N, RdRP, 166 and S indicate that these genes tend to evolve faster compared to other ones. A plausible explanation 167 for this observation is that protein N due to its immunogenicity, has been frequently used to generate 168 specific antibodies against various .....
Document: Genes M and E show quite low slopes, indicating that these proteins tend to evolve slowly by 165 accumulating nucleotide mutations on their genes. Conversely, the steeper slopes for genes N, RdRP, 166 and S indicate that these genes tend to evolve faster compared to other ones. A plausible explanation 167 for this observation is that protein N due to its immunogenicity, has been frequently used to generate 168 specific antibodies against various animal coronavirus, including in SARS [24] . The viral replicase 169 polyprotein that is essential for the replication of viral RNA and, finally, the gene S encodes the protein 170 that is responsible for the "spikes" present on the surface of coronaviruses. Taken together, our results 171 suggest that the higher evolutionary rate observed for these proteins could represent a major obstacle 172 to in the development of a antiviral therapeutics against 2019-nCoV. 173 author/funder. All rights reserved. No reuse allowed without permission.
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