Research Communications of the 27(th) ECVIM-CA Congress: Intercontinental, Saint Julian's, Malta, 14th to 16th September 2017

ECSs with CP presenting to the QVSH between December 2011 and March 2017 were recruited. CP was diagnosed either with pancreatic histology (n = 2) or with both elevated cPLI and abnormal pancreatic ultrasound (n = 9, of which one had positive fine needle aspirate cytology). Case records were searched for details of signalment, clinical and clinicopathological findings, particularly evidence of keratoconjunctivitis sicca (KCS); xerostomia; proteinuria or other immune-mediated diseases. 20 ECS presented with suspected CP but only 12 dogs fulfilled the strict inclusion criteria. There were 8 females and 4 males. Median age was 9 years (range 4. 3-14 years). 6/10 dogs were blue roan and 1/10 was orange roan. All dogs had gastrointestinal signs and pain. 7/10 dogs where tears were checked had KCS. 6/7 cases had dry oral mucous membranes suggesting xerostomia; 8/11 dogs had proteinuria (Urine protein:creatinine ratio range 0.7-8.3). 4 cases had UPC <2 but in 2/4 cases it increased >2 on subsequent visits. Glomerulonephritis was confirmed post mortem in one dog. Two dogs had atopy; one had inflammatory bowel disease and one had pemphigus foliaceus. Three dogs had biliary tract disease. One dog had epilepsy and two dogs developed intervertebral disc disease. Three dogs had large mass lesions in the pancreas which resolved on symptomatic treatment. CP in ECSs shows remarkable clinical similarities to human IgG4-RD with a high prevalence of KCS, xerostomia, proteinuria and other immune-mediated diseases. Affected dogs can present with benign mass-like pancreatic lesions. The disease appears to be more common in blue roan dogs.