Author: Lan, Jiaming; Yao, Yanfeng; Deng, Yao; Chen, Hong; Lu, Guangwen; Wang, Wen; Bao, Linlin; Deng, Wei; Wei, Qiang; Gao, George F.; Qin, Chuan; Tan, Wenjie
Title: Recombinant Receptor Binding Domain Protein Induces Partial Protective Immunity in Rhesus Macaques Against Middle East Respiratory Syndrome Coronavirus Challenge() Document date: 2015_8_18
ID: q8i2gfut_33
Snippet: To assess the T-cell immune response, rhesus macaque PBMCs derived at different times following rRBD immunisation were stimulated with overlapping synthetic peptides of RBD; ELISpot analyses were then conducted. Immunisation with rRBD proteins induced antigen specific IFN-γ-secreting T-cells. In addition, high-dose rRBD induced significantly higher levels of IFN-γ-secreting T-cells (Fig. 2f) ......
Document: To assess the T-cell immune response, rhesus macaque PBMCs derived at different times following rRBD immunisation were stimulated with overlapping synthetic peptides of RBD; ELISpot analyses were then conducted. Immunisation with rRBD proteins induced antigen specific IFN-γ-secreting T-cells. In addition, high-dose rRBD induced significantly higher levels of IFN-γ-secreting T-cells (Fig. 2f) .
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