Recent Advances in Biosensor Development for Foodborne Virus Detection

Neethirajan, Suresh; Ahmed, Syed Rahin; Chand, Rohit; Buozis, John; Nagy, Éva

A one-tube colorimetric and surface plasmon resonance (SPR) active nanoparticle platform is used to detect hepatitis A and B viruses simultaneously and quantitatively with picomolar sensitivity, which is archived by eliminating spectral overlap through non-negative matrix factorisation [63] . Another nanomaterial platform combines sandwich immunoassay, fluorescent labeling, and magnetic separation together to detect hepatitis A and B virus DNA with high sensitively, easy operation, quantitative quality, and picomolar detection up to 0.1 pM [51] . An additional Au gold probe is used to measure hepatitis A and B viruses with restriction-enzyme-encoded DNA-modified magnetic in dark filed image with sensitivity up to 0.1 pM [64] . It has a great versatility and multiplexed possibility due to the availability of more than 2,000 restriction enzyme choices.