Selected article for: "high dose group and low dose"
Author: Lan, Jiaming; Yao, Yanfeng; Deng, Yao; Chen, Hong; Lu, Guangwen; Wang, Wen; Bao, Linlin; Deng, Wei; Wei, Qiang; Gao, George F.; Qin, Chuan; Tan, Wenjie
Title: Recombinant Receptor Binding Domain Protein Induces Partial Protective Immunity in Rhesus Macaques Against Middle East Respiratory Syndrome Coronavirus Challenge()
  • Document date: 2015_8_18
    • ID: q8i2gfut_36
    Snippet: To monitor signs of pneumonia in MERS-CoV challenged animals, Xray examination was performed 1 day pre-, 1 and 3 days after MERS-CoV inoculation. Radiography revealed that all monkeys were negative for pneumonia before MERS-CoV challenge (−1 day). In mock group animals, local interstitial inflammation was detected at 1 dpi, with pneumonia diffused to adjacent pulmonary lobes at 3 dpi. Pneumonia generated in the high-dose group was delayed to 3 .....
    Document: To monitor signs of pneumonia in MERS-CoV challenged animals, Xray examination was performed 1 day pre-, 1 and 3 days after MERS-CoV inoculation. Radiography revealed that all monkeys were negative for pneumonia before MERS-CoV challenge (−1 day). In mock group animals, local interstitial inflammation was detected at 1 dpi, with pneumonia diffused to adjacent pulmonary lobes at 3 dpi. Pneumonia generated in the high-dose group was delayed to 3 dpi, with infiltration confined to a single lobe (Fig. 3a) . Although pneumonia was detected in low-dose monkeys at 1 dpi, infiltration and interstitial inflammation was less severe compared with the mock group.

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