Quantitative determination of residual 1,4-dioxane in three-dimensional printed bone scaffold

Li, Ling; Long, Jing; Li, Long; Cao, Huijuan; Tang, Tingting; Xi, Xinghua; Qin, Ling; Lai, Yuxiao; Wang, Xinluan

It was reported that 1,4-dioxane was determined reliably in water by various techniques including direct aqueous injection, purge and trap gas chromatographymass spectrometric (GC-MS), and GC-MS analysis of continuous liquideliquid extraction extracts [30] . Conventional purge and trap GC-MS is strictly limited by poor purge efficiency of 1,4-dioxane whose detection limit is about 100 times higher than those efficiently purged volatile organic compounds [30] . Headspace GC-MS (HS-GC-MS) was used commonly in the determination of poorly purged organic solvents in cosmetics [31] as it could reach the target compound to eliminate the background interference in special boiling point of volatile organic compounds. Therefore, HS-GC-MS was chosen as an analysis method for scaffolds to simplify the pretreatment process and acquire high quantity chromatogram or spectrum.