Selected article for: "cell type and lymphoid cell"

Author: Sato, Hiroki; Yoneda, Misako; Honda, Tomoyuki; Kai, Chieko
Title: Morbillivirus Receptors and Tropism: Multiple Pathways for Infection
  • Document date: 2012_3_1
  • ID: xic32wxh_54
    Snippet: Investigations aimed at identifying the receptors for morbillivirus started in 1993 with CD46 for vaccine strains of MeV, followed by the lymphoid cell receptor, SLAM, in 2000, and the epithelial cell receptor, nectin-4, in 2011, for wild-type viruses. Along with the receptors, the cell tropism, transmission modes in the body, and unique pathogenicities of morbillivirus are being explained. However, many problems associated with morbillivirus rem.....
    Document: Investigations aimed at identifying the receptors for morbillivirus started in 1993 with CD46 for vaccine strains of MeV, followed by the lymphoid cell receptor, SLAM, in 2000, and the epithelial cell receptor, nectin-4, in 2011, for wild-type viruses. Along with the receptors, the cell tropism, transmission modes in the body, and unique pathogenicities of morbillivirus are being explained. However, many problems associated with morbillivirus remain to be clarified. In particular, the mechanism by which MeV spreads in the central nervous system during fatal subacute sclerosing panencephalitis is unknown. Further studies will lead to a better understanding of morbillivirus pathogenesis and to novel strategies for treatment and prevention.

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