Author: Taguchi, Fumihiro; Hirai-Yuki, Asuka
Title: Mouse Hepatitis Virus Receptor as a Determinant of the Mouse Susceptibility to MHV Infection Document date: 2012_2_24
ID: uweg32sf_7
Snippet: The molecule on MHV virion that binds to the receptor is the spike (S) protein with ca. 180-200 kDa class I fusion glycoprotein (Bosch et al., 2003) . One spike is composed of a trimer of the S protein. The S protein of most MHV is cleaved in the middle of the molecule, and the N terminal subunit is called the S1 and C terminal subunits S2, respectively (Sturman et al., 1985) . N terminal 330 amino acids in S1 are responsible for receptor binding.....
Document: The molecule on MHV virion that binds to the receptor is the spike (S) protein with ca. 180-200 kDa class I fusion glycoprotein (Bosch et al., 2003) . One spike is composed of a trimer of the S protein. The S protein of most MHV is cleaved in the middle of the molecule, and the N terminal subunit is called the S1 and C terminal subunits S2, respectively (Sturman et al., 1985) . N terminal 330 amino acids in S1 are responsible for receptor binding (Kubo et al., 1994) , and S2 is critical for envelope-cell membrane fusion, namely, cell entry (Bosch et al., 2003) .
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